![]() ![]() Grapefruit juice decreases the activity of the cytochrome P450 3A4 (CYP3A4) enzymes that are responsible for breaking down many drugs and toxins.Grapefruit or grapefruit juice can alter enzymes in the body and affect how drugs are changed in the body before they are eliminated. ![]() Why does grapefruit interact with drugs?ĭrugs or toxins are usually broken down (metabolized) so that they can be eliminated from the body. Some immunosuppressants have been reported to cause kidney damage, and certain pain medications when mixed with grapefruit juice may be linked with depressed breathing. Check with your pharmacist or doctor to confirm any interactions you may find.Įxamples of common medications that interact with grapefruit juice include certain statin cholesterol drugs such as atorvastatin (Lipitor), lovastatin, simvastatin (Zocor), felodipine (Plendil) and other calcium channel blockers, clarithromycin (Biaxin), and loratadine (Claritin). New drugs are approved frequently, so it is wise to research your drug interactions with grapefruit juice drug with the Drugs Interaction Checker.This can lead to enhanced side effects or lower drug effectiveness. Grapefruit juice affects how drugs are changed (metabolized) in the body for eventual elimination and can alter the amount of drug in your blood.Interactions with grapefruit can occur with common and important medications - such as those that lower cholesterol, treat high blood pressure, or even those that fight cancer.Grapefruit juice interactions can even occur with over-the-counter (OTC) drugs. Maybe you've receive a medication prescription container with an affixed warning label that recommends you avoid grapefruit or grapefruit juice while taking the medication. While grapefruit is a nutritious fruit, many patients are concerned about the potential for drug interactions with grapefruit juice. Which drugs interact? | Why does grapefruit juice interact with drugs? | Possible side effects | Timing | Which other juices interact? | Common drugs that interact with grapefruit juice | Other resources Which drugs interact with grapefruit juice? Eat more, weigh less?.Medically reviewed by Leigh Ann Anderson, PharmD. doi:10.1089/jmf.2006.9.49Ĭenters for Disease Control and Prevention. The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome. Content of phenolic compounds and vitamin C and antioxidant activity in wasted parts of Sudanese citrus fruits. Grapefruit juice and some drugs don't mix.īourrier T, Pereira C. Before grabbing a grapefruit, understand its power. Grapefruit-medication interactions: Forbidden fruit or avoidable consequences? CMAJ. 2013 185(4):309-16. Don't take this with that: Grapefruit causes problems when taken with certain medications.īailey DG, Dresser G, Arnold JMO. Consumption of grapefruit is associated with higher nutrient intakes and diet quality among adults, and more favorable anthropometrics in women, NHANES 2003–2008. FoodData Central: Grapefruit, raw, pink and red, all areas. Citrus essential oils in aromatherapy: therapeutic effects and mechanisms. Vitamin C intake and cancers: an umbrella review. The effects of daily consumption of grapefruit on body weight, lipids, and blood pressure in healthy, overweight adults. A systematic review on the role of vitamin C in tissue healing. ![]()
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