Grapefruit juice decreases the activity of the cytochrome P450 3A4 (CYP3A4) enzymes that are responsible for breaking down many drugs and toxins.Grapefruit or grapefruit juice can alter enzymes in the body and affect how drugs are changed in the body before they are eliminated. Why does grapefruit interact with drugs?ĭrugs or toxins are usually broken down (metabolized) so that they can be eliminated from the body. Some immunosuppressants have been reported to cause kidney damage, and certain pain medications when mixed with grapefruit juice may be linked with depressed breathing. Check with your pharmacist or doctor to confirm any interactions you may find.Įxamples of common medications that interact with grapefruit juice include certain statin cholesterol drugs such as atorvastatin (Lipitor), lovastatin, simvastatin (Zocor), felodipine (Plendil) and other calcium channel blockers, clarithromycin (Biaxin), and loratadine (Claritin). New drugs are approved frequently, so it is wise to research your drug interactions with grapefruit juice drug with the Drugs Interaction Checker.This can lead to enhanced side effects or lower drug effectiveness. Grapefruit juice affects how drugs are changed (metabolized) in the body for eventual elimination and can alter the amount of drug in your blood.Interactions with grapefruit can occur with common and important medications - such as those that lower cholesterol, treat high blood pressure, or even those that fight cancer.Grapefruit juice interactions can even occur with over-the-counter (OTC) drugs. Maybe you've receive a medication prescription container with an affixed warning label that recommends you avoid grapefruit or grapefruit juice while taking the medication. While grapefruit is a nutritious fruit, many patients are concerned about the potential for drug interactions with grapefruit juice. Which drugs interact? | Why does grapefruit juice interact with drugs? | Possible side effects | Timing | Which other juices interact? | Common drugs that interact with grapefruit juice | Other resources Which drugs interact with grapefruit juice? Eat more, weigh less?.Medically reviewed by Leigh Ann Anderson, PharmD. doi:10.1089/jmf.2006.9.49Ĭenters for Disease Control and Prevention. The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome. Content of phenolic compounds and vitamin C and antioxidant activity in wasted parts of Sudanese citrus fruits. Grapefruit juice and some drugs don't mix.īourrier T, Pereira C. Before grabbing a grapefruit, understand its power. Grapefruit-medication interactions: Forbidden fruit or avoidable consequences? CMAJ. 2013 185(4):309-16. Don't take this with that: Grapefruit causes problems when taken with certain medications.īailey DG, Dresser G, Arnold JMO. Consumption of grapefruit is associated with higher nutrient intakes and diet quality among adults, and more favorable anthropometrics in women, NHANES 2003–2008. FoodData Central: Grapefruit, raw, pink and red, all areas. Citrus essential oils in aromatherapy: therapeutic effects and mechanisms. Vitamin C intake and cancers: an umbrella review. The effects of daily consumption of grapefruit on body weight, lipids, and blood pressure in healthy, overweight adults. A systematic review on the role of vitamin C in tissue healing.
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Cellular and GPS coverage is required to use most features. reserves the right to change or discontinue Kia Connect at any time without prior notification or incurring any future obligation. Kia Access App is available from the Apple® App Store® or Google Play Store™. Kia Connect may currently be unavailable for Model Year 2022 and newer vehicles sold or purchased in Massachusetts please see the Kia Owners Portal for updates on availability. Complimentary Kia Connect subscription is transferable to subsequent owner during the original Kia Connect service term. Use of Kia Connect is subject to agreement to the Kia Connect Privacy Policy (available at /us/en/privacy-policy.html) and Terms of Service (available at /us/en/terms-of-service.html. After your complimentary 1-year Kia Connect subscription expires, continued access to the full suite of Kia Connect services available on your Kia will require a paid subscription at the then-current subscription rate or your use of certain Kia Connect features may immediately terminate. Purchase/lease of a 2022 Kia with Kia Connect includes a complimentary 1-year subscription starting from new vehicle retail sale/lease date as recorded by the dealer. Features, colors, materials, accessories and specifications on pre-production model may vary from production model. Pre-production Soul model with optional features shown. JQuery Interactive 3D let you create a 3D interactive object using several images as frames allowing the user to drag around and manipulate the image. Best suited for silhouettes, like font icon SVGs. It’s rather processor-intensive, so please use responsibly.Ī high-level module to convert a SVG path string into a 3D triangulated mesh. Photon is a JavaScript library that adds simple lighting effects to DOM elements in 3D space. The goal of this project is to provide a lightweight 3D CSS library with very simple implementation. Turbulenz is a modular 3D and 2D game framework for making HTML5 powered games for browsers, desktops and mobile devices. It uses WebGL for hardware-accelerated graphics, and is cross-platform, cross-browser, and tuned for dynamic-data visualization.Ī WebGL graphic library for building scalable Web3D applications. It wraps physics, lighting, surfaces, textures in a yet simple and powerful API.Ī WebGL-based 3D engine for technical visualization.ĬesiumJS is a JavaScript library for creating 3D globes and 2D maps in a web browser without a plugin. It uses HTML5 and WebGL to run games and other interactive 3D content in all modern browsers without the need for a plugin. Its geometries exist in 3D space, but are rendered as flat shapes. With Zdog, you can design and render simple 3D models on the Web. Zdog is a 3D JavaScript engine for canvas and SVG. BabylonJS takes away a lot of the complexity involved with programming in WebGL. WebGL API is used for rendering graphics within a web browser. With A-frame, a lot of the grunt-work is simplified.īabylon is a javascript framework that is built above the Web Graphics Library. WebGL originally made it possible to build VR for the web, but it took many lines of code to setup a simple scene. Three.js is a high-level cross-browser 3D Javascript graphics library and API that allows you to render 3D computer graphics on your browser, established by Ricardo Cabello in 2010 and now supported by a wide community.Ī-Frame is an open source javascript framework for building VR on the web. So here we present 20 Interactive 3D Javascript Libraries & Frameworks for creating 3D graphics on the web. And one of the new exiting possibilities is the rendering of interactive 3D graphics within the browser. This chapter covered the two different animation mechanisms support by Quintus: keyframe and tweening.Modern browsers have evolved drastically. chain works the exact same way as animate, except it calculates the delay automatically to start after the currently playing animation and stop stops all currently playing animations Chapter Summary The component also adds two additional methods to the Sprite: chain and stop. callback - a callback to trigger when the animation is done.delay - a delay in seconds before starting the animation.The final options hash currently supports two options: Q. - start slow, accelerate, decelerate and end slow.Q.Easing.Linear - map linearly from 0 to 1.Quintus has a few easing functions built-in (taken from Tween.js) Duration is a duration in seconds and easing is an easing function that takes in a value from 0 to 1 and returns a number from 0 to 1. Where properties is a hash of properties for the end result (you can use set before hand if you need to set the initial state. If you want more control over animations, the full method signature for animate is: function animate(properties, ) This will animate the sprite linearly over the course of 1 second. Here's an example: var Q = Quintus().include("Sprites, Anim") Setting up animation spritesīefore you can add in frame animations to a Sprite, you need to create an animation sheet by calling Q.animations and passing in a name and the details about the different named animations. The first works by setting up sprites that work with sprite sheets to define animations (stuff like walk left, walk right, jump, etc) the second by animating properties of sprites via keyframes. The Quintus Anim module adds in support for both frame based animation and tween based animation via two components: animation and tween. Quintus is an easy-to-learn, fun-to-use JavaScript HTML5 game engine You can help the Assassin's Creed Wiki by expanding it. The Eastern Roman Empire continued, however for almost another 1,000 years before it too saw its capital, Constantinople, conquered, this time by the rising Ottoman Empire, in 1453. Divided between the Western Roman Empire and the Eastern Roman Empire, the two bodies continued to co-exist until the Sack of Rome, and the collapse of the Western Roman Empire in 476 CE. For news, discussion and more about Ubisoft's Assassin's Creed franchise. 418k members in the assassinscreed community. Downfall Įventually, due to its vast size, it was decided that the Empire should fragment in order to better govern it various territories. What do you guys think of the Centurian armor from Origins making a return in Vikings Personally I would love to see it : assassinscreed 228 votes, 40 comments. Under his reign, the empire reached its largest territorial size, and numerous constructions projects were undertaken in Rome. The Roman armor is the leather set within Assassin's Creed Brotherhood.Similar to the leather armor in Assassin's Creed 2, it doesn't mesh well with the robes of the Brotherhood, but it does at. He was succeeded by his son, Titus, who crushed a Jewish rebellion and sacked Jerusalem. Become a fierce fighter of Rome in Assassin's Creed Origins with the Roman Centurion gear pack, available now for Season Pass owners. He undertook several great construction projects, including the Colosseum, a large amphitheatre built atop a Isu Temple. The Flavian dynasty of emperors was founded by Vespasian, who ruled from 69 CE to 79 CE. Nero committed suicide in 68 CE, ending the Julio-Claudian dynasty of emperors. It is rumored that he intentionally started the Great Fire of Rome in 64 CE in order to build his lavish Golden Palace. One of Caligula's successors, Nero, was renowned for his supposed tyranny and extravagnace. In 41 CE, the Assassin Leonius stabbed him to death with a dagger. Regarded as an insane ruler, he was also supported by the Templars. In 37 CE, Caligula rose to become Roman Emperor. “In previous generations, when the wire on the EDM broke, it had to be cut and go back to the start point and retrace through the wire kerf to the break point and re-start machining,” said Bystrek. This provides two advantages: time savings and maximum unattended time. It’s the best way to improve reliability and reduce machine downtime.”īy annealing the wire, users can thread (while submerged) almost any size start hole reliably and thread directly through the gap at the break point. “It’s why we recommend annealing the wire to make it as straight as possible by removing memory from being wound on the spool. “Without reliable wire threading the process is pretty much worthless,” said Bystrek. The two key considerations for cost-effective wire EDM performance are reducing wire consumption and auto threading the wire itself. This allows us to slow the wire speed down without impacting machine performance while reducing wire consumption by over 60 percent over previous models,” said Bystrek. Making that possible is incorporation of fiber optics and the High-Speed Spark Detection System, which optimizes the spark shape to remove more workpiece material while reducing wear on the wire. “The steps we’ve taken on the wire side with our MV series have reduced hourly cost significantly by reducing wire electrode consumption. Mike Bystrek, national wire EDM product manager, and Pat Crownhart, national sinker EDM product manager, for MC Machinery Systems Inc., Elk Grove Village, Illinois, describe the challenge to EDM technology to produce the fastest, lowest cost and most accurate ways to manufacture workpieces. Wire EDM and sinker EDM each have benefited from technologies that lower the cost of manufacturing. The new AgieCharmilles CUT C 350 wire EDM has a cost-effective $99,000 starting price point provides optimized cutting speed and reliable accuracy and its AC CUT HMI 2 system makes for easy programming through efficient EDM expert modules, according to the manufacturer.Īt the same time, as more traditional machining processes are advancing their capabilities, EDM, and especially wire EDM, is finding new applications in additive manufacturing by cutting off high-value 3D printed components from their backing plates or in precision hole drilling for aerospace engines. Machine tool builders continue to tackle EDM improvements by increasing operating speeds, reducing wire consumption, improving auto threading for lights-out operation and improving spark generating power supplies. Manufacturers of products as diverse as die and mold, aerospace and medical devices are gaining advantage with improved wire and sinker electrical discharge machines (EDM). Advanced EDM technology is putting more and better parts in the bin faster For us, the key has always been to put the customer’s experience first. “With this partnership, our customers can enjoy unparalleled levels of convenience, security, and functionality, all through Pitney Bowes’ best-in-class platform and Luxer One’s industry-leading smart locker platform. “Our team is excited to partner with Pitney Bowes to bring our integrated solutions to the market together,” says Arik Levy, CEO/Founder of Luxer One, which is a division of global access leader, ASSA ABLOY. Accurate chain of custody tracking keeps mailroom managers updated in real-time and provides organizations with reliable performance measures. When recipients arrive at the lockers to collect their packages, they sign in on the locker’s touch screen and a camera will take their photo. “The partnership demonstrates Pitney Bowes’ firm and continued commitment to delivering innovative technologies which simplify sending for businesses.” Together, the technologies deliver a streamlined, automated system which boosts mailroom efficiency and delights package recipients,” said Jason Dies, EVP and Vice President Sending Technology Solutions, Pitney Bowes. “This exciting new partnership brings together Luxer One’s sophisticated locker technology and SendSuite Tracking Online’s innovative package tracking platform, built on our deep carrier market intelligence. A cloud-based tracking solution, SendSuite Tracking Online streamlines the logging, tracking and managing of incoming packages and important mail, sending notifications, parcel location details and secure digital passcodes or barcodes to recipients’ mobiles. Robust, custom-color lockers with touch screen technology provide secure physical storage in convenient locations, while Pitney Bowes’ SendSuite Tracking Online adds an extra layer of security and visibility. The secure intelligent parcel management solution generated by the Pitney Bowes and Luxer One collaboration is ideal for use by larger enterprises, retailers, higher education and local government agencies in which high volumes of time-sensitive shipments are received, tracked and distributed. Pitney Bowes Intelligent Lockers featuring Luxer One, sees industry-leading SendSuite® Tracking Online from Pitney Bowes integrate with the sophisticated functionality of Luxer One intelligent lockers, creating a smart new way to meet increasing package and mail delivery demands. The collaboration demonstrates Pitney Bowes’ firm commitment to this fast-growing market. (NYSE: PBI), a global technology company that provides commerce solutions in the areas of ecommerce, shipping, mailing, data and financial services, today announced a partnership with Luxer One, a leader in intelligent locker and parcel management solutions. SendSuite ® Tracking Online was designed with security in mind, allowing legal documents to be tracked until they reach their recipients with assured accountability and a transparent chain of custody.STAMFORD, Conn.-( BUSINESS WIRE)-Pitney Bowes Inc. In a legal office, receiving documents that contain sensitive information is part of the job. Track packages securely at your law firm with peace of mind.Staff won’t need to constantly check to see who is working in the office that day and employees will be free to pick up their mail when they’re in the office. Combined with our Smart Locker systems, your business will be primed for the new normal of work. SendSuite Tracking Online also makes tracking and delivering packages in hybrid work environments easier. SendSuite ® Tracking Online allows mail center staff to account for inbound packages using their computer or mobile device. Package tracking within corporate offices has never been easierīetween dealing with employees’ outgoing mail, keeping mailing supplies stocked and sorting incoming packages, it can be difficult to keep track of packages.This intuitive delivery tracking software reduces data entry time and any human error that comes with it. With hundreds of medical professionals working different shifts, getting packages to their rightful recipients can be a matter of improving the quality of patient care.
The viewability of some impressions can't be determined, which are known as non-measurable impressions. Note: This is not the viewability rate of your ad. Total impressions include both measurable and non-measurable impressions. This distribution metric shows the percentage of your total ad impressions that were viewable. This metric can help you understand how often your ad appeared in places that were able to be measured by Active View technology. Measurable rate - Measurable impressions over total impressions represents the percentage of your total impressions that were measured by Active View.This percentage estimates how many of your measurable impressions were actually viewable to potential customers. It’s the percentage of time when your ad appeared on sites or apps with Active View enabled and was viewable. Viewable rate - This is the viewability rate of your ad.It can help you understand how often your ad appeared where people could notice it. An ad is counted as viewable if at least 50% of its area is visible for at least 1 second for display ads, or at least 2 seconds for video ads. This metric shows the number of times your ad’s impressions were considered viewable. This metric can help you understand how often your ad appeared in locations measured by Active View. Not all impressions are measurable by Active View, as some factors may prevent the data from being captured. Measurable impressions represent the number of times your ad appeared in locations on websites or apps that could be measured by Active View technology. An impression is counted whenever your ad is served. These metrics are available for Video and Display campaigns: Read more detailed descriptions of these metrics below. Measurable rate - This metric shows how often your ads were able to be measured by Active View.Viewable rate - This metric shows how often your ads were both measurable by Active View and viewable by users.If you’re just getting started with using Active View metrics, here are some key metrics to understand: A video ad is counted as viewable when at least 50% of its area is visible on the screen while the video is playing for at least 2 seconds.For large display ads of 242,500 pixels or more, the ad is counted as viewable when at least 30% of it’s area is visible for at least 1 second.A display ad is counted as viewable when at least 50% of its area is visible on the screen for at least 1 second. According to MRC guidelines, the standard for measuring the viewability of ads are as follows: Active View metrics can be used for Video and Display campaigns to help you better understand how often your ad appears in a position on a webpage, device, or app that people can notice.Īctive View metrics have been created in compliance with industry standards for measuring the viewability of online ads, as developed by the Media Rating Council (MRC). Beginning June 2023, we’ll switch to using the Open Measurement (OM) SDK, an industry standard for ad viewability measurement, for video inventory on the web.Īctive View is a technology on YouTube and certain Display Network websites and apps that allows Google Ads to determine if your ad is viewable by potential customers. Before you use interferon beta-1a intramuscular for the first time, you or the person who will be giving the injections should also read the manufacturer's information for the patient that comes with it. Ask your doctor or pharmacist to show you or the person who will be injecting the medication how to inject it. After that, you can inject interferon beta-1a intramuscular yourself or have a friend or relative perform the injections. You will receive your first dose of interferon beta-1a intramuscular in your doctor's office. Do not stop using interferon beta-1a without talking to your doctor. Continue to use interferon beta-1a even if you feel well. Interferon beta-1a controls the symptoms of MS but does not cure it. Do not use more or less of it or use it more often than prescribed by your doctor. Use interferon beta-1a exactly as directed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Inject interferon beta-1a intramuscular at around the same time of day on your injection days. This medication is injected into a muscle, usually once a week, on the same day each week. Interferon beta-1a intramuscular injection also comes as a solution (liquid) in prefilled injection syringes and in a prefilled automatic injection pen. Interferon beta-1a intramuscular injection comes as a powder in vials to be mixed into a solution for injection. 1970s detroit tigers magazines - $20 (Charlotte)ģ fairly good shape magazines from late 70s.1970s Hot Rod Magazines - $2 (Manchester).Lots of full-page, color photos of classic hot rods, Corvettes, and muscle cars! “Hot Rod” magazine, “Popular Hot Rodding,” “1001 Custom and Rod Ideas,” “Cars” maga. Loaded with pictures and articles about hot rods, racing, and working on cars. 1970s Hot Rod Magazines - $40 (Manchester)Ģ0 hot rod magazines from 1975 – 1977. Prices very by piece.Some items in photos have already sold - I try my best to update as quickly as possible.We have an assortment of vintage Star Wars toys in stock including action figures, playsets, storage cases, comics, model kits, games, etc. ♦♦ Vintage Star Wars 1970s-90s Action Figure Model Playsets Etc.Lots of fun articles about lost treasure from days gone by, with useful clues about where it may be and how you could find i. We've gathered more than 5 Million Images uploaded by our users and sorted them by the most popular ones. “Lost Treasure” from September, 1976 “Lost Treasure” from January, 1976 and “True Treasure” from February, 1974. Explore a curated colection of Easy Rider Girls Wallpaper Images for your Desktop, Mobile and Tablet screens. Lot of 11 vintage easy rider magazines 1993 with centerfolds. Please Text or Email only.Be sure to view all our other ads. We have 40 David Mann centerfold posters.5 for each magazine with centerfold, 5 for each David Mann centerfold with a magazine includedWe just ask that you purchase at least 4. 19 are complete with David Mann centerfold, 35 have the centerfold removed. Lot of 2 Vintage Biker Magazines 1970’s Easy Riders. We have Easyrider magazines for the 70s, 80s and 90s. 1984 85 86 87 Easyrider Motorcycle Magazines Vintage Bulk lot 5 Total. Three treasure hunting magazines from the 1970s. Vintage 1970s- 2000s Motorcycle Magazine Easy Rider Lot ×35. 1970s Treasure Hunting Magazines - $3 (Manchester).16 Penthouse and 2 old Playboy magazines. Mens magazines 1970s-90s Penthouse and Playboy $100ġ8 men's / adult magazines.Would like to Sell or trade entire collection. Also have other related magazine inserts. 36 In The Winds, issues 121 to 165, not all issues. 62 Easy riders, issues from 156 to 554, not all issues. Easy Rider, In The Wind, Playboy Collection - $1 (Benton city)ġ36 Playboys, 1971-2015, not all issues.Thanks!)Kevlar EasyRider Eskimo 17 Kayak. Instead, please call or text us at 425-51six-4249 or use a non-Yahoo email account to correspond on. Yahoo Email has a known bug which causes it to lose emails, or to hide it in the Spam folder. (Note: Please don't use a Yahoo Email to reply to ads. Kevlar Easy Rider Expedition Kayak with Kayak Sail (2 available) - $2795 (Anacortes).Over 100 pieces includes various motorcycle parts catalogs. Vintage Iron Horse/Easy Rider magazine collection - $75 (Eugene)ĭeceased loved ones vintage Iron Horse/Easy Rider/Harley Women magazine collection.ORIGINAL APRIL 1983 EASYRIDERS MAGAZINE - DAVID MANN CENTERFOLD - VG CONDITION. Get cozy and expand your home library with a large online selection of books at. Also includes Iron Horse, Jammer, and other motorcycle mags. Great deals on Easyrider David Mann In Magazine Back Issues. Easy Rider Magazine Collection - $1,000 (Hampton)Īlmost complete 1971 to 1985 Easy Rider Collection.Also includes Iron Horse, Jammer, and other motorcycle mags. Easy Rider Magazine Collection - $1,200 (Hampton)Īlmost complete 1971 to 1985 Easy Rider Collection.Approximately 140 David Mann Easy Rider centerfolds $400 Possible Medford delivery Bob. With PHP 5.4 or newer, you can start learning PHP without installing and configuring a full-fledged web server. If you are not sure which version a function or feature is in, you can check the PHP documentation on the php.net website. Upgrading is easy, as there are not many backwards compatibility breaks PHP 8.0, PHP 8.1, PHP 8.2. You should try to upgrade to the latest stable version quickly - PHP 7.4 is already End of Life. PHP 8 is a major update of the language and contains many new features and optimizations. The engine has been largely re-written, and PHP is now even quicker than older versions. PHP 8.x adds many new features over the older 7.x and 5.x versions. If you are getting started with PHP, start with the current stable release of PHP 8.2. Help make this website the best resource for new PHP programmers! Contribute on GitHubīack to Top Getting Started Use the Current Stable Version (8.2) The most recent version of PHP: The Right Way is also available in PDF, EPUB and MOBI formats. PHP: The Right Way is translated into many different languages: This is a living document and will continue to be updated with more helpful informationĪnd examples as they become available. Instead offer suggestions for multiple options, when possible explaining the differences This website will also not tell you which tools to use, but To give seasoned pros some fresh ideas on those topics they’ve been doing for years This website aims to introduce new PHPĭevelopers to some topics which they may not discover until it is too late, and aims Quick reference for PHP popular coding standards, links to authoritative tutorialsĪround the Web, and what the contributors consider to be best practices at present. Propagating bad practices and insecure code. If the post is not found, it is perfectly fine and common to return a 404.īut you can also choose to handle it yourself.There’s a lot of outdated information on the Web that leads new PHP users astray, This is ideal for situations with urls like /posts/edit/5, where 5 represents the post id. Laravel will automatically catch the exception and returns a 404 Not found page. If you choose for option 1, you don't need to do anything, except just appending OrFail() to your methods. In the case of findOrFail() and firstOrFail(), Laravel throws an **Illuminate\Database\Eloquent\ModelNotFoundException** when it does not find a model. Let Laravel catch and handle the exception automatically. In this situation, when we're talking about not finding Eloquent records from the database, you have two options: Else it falls to the ground and the game ('app') grinds to a halt. Sounds logical, right? If someone throws a ball, someone needs to catch it. If an exception is thrown, then you need to catch it. That sounds scary – I mean, why would you want to manually throw exceptions, if you're only working to fix them? But it isn't scary at all. In this case, when Eloquent did not find an object, it throws an exception. In this article I'll use the default Eloquent User model. So let's just get started and show a few examples. This gives you extreme versatility and allows you to perform almost any database operation. For example: $user = User::first() or $ralph = new User. For example: $users = User::all() gets all users. Interact with the database table as a whole. An Eloquent model is just a PHP class, that allows you to do two things: So, what is Eloquent exactly? Or what is an Eloquent model? It effectively comes down to the following: for each table you have in your database, you create an Eloquent model. In this tutorial I'll show you the basics of using Laravel Eloquent, so that you can start using Eloquent quickly. The Laravel Eloquent ORM is a way to interact with your database. Laravel Eloquent is one of Laravel's flagship features and one of the most notable things that distinguishes Laravel from other PHP frameworks. |
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